The dose of nitroprusside used in each group did not differ statistically. When hydroxocobalamin infusion was stopped before sodium nitroprusside infusion was discontinued, blood cyanide levels and base deficit increased in a manner similar to that in the untreated group.

Acidosis developed in patients with red-cell cyanide levels higher than 75 μg per 100 ml. Red-cell and plasma cyanide levels were 83.44± 23.12 and 3.51☑.01 μg 100 ml after nitroprusside alone and were 33.18☑7.29 and 2.18☐.65 μg per 100 ml after nitroprusside plus hydroxocobalamin.

One group received nitroprusside alone, and the other received nitroprusside and hydroxocobalamin. To investigate hydroxocobalamin's role in preventing cyanide intoxication from sodium nitroprusside, we studied two groups of patients. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills.

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Hydroxocobalamin for cyanide poisoning